Toll Free: (855) 688-9653

Chemotherapy for Mesothelioma

Chemotherapy is recommended for many people with pleural mesothelioma. It can be used as a primary treatment or in combination with surgery or radiation therapy in an approach called multimodal treatment.

Get a Free Treatment Guide

Can Chemotherapy Cure Mesothelioma?

While chemotherapy improves length and quality of life for people with a pleural mesothelioma diagnosis, it does not cure the disease.

Cancer cells grow, divide and multiply more rapidly than normal cells. Chemotherapy drugs for pleural mesothelioma attack these rapidly growing cells. This is why chemotherapy is recommended for many patients.

However, chemotherapy for pleural mesothelioma offers patients the opportunity to control this aggressive cancer for better survival and improved prognosis.

Most normal cells do not grow as rapidly as mesothelioma cells, but these drugs affect some of these cells. Hair, skin and gastrointestinal tract cells are susceptible to chemotherapy.

This is reflected in the side effects some pleural mesothelioma patients experience such as hair loss, dry skin, rashes, nausea, mouth sores and altered sense of taste.

How Is Chemotherapy Used to Treat Pleural Mesothelioma?

Chemotherapy may be used as the primary pleural mesothelioma treatment, especially if the patient is not able to undergo mesothelioma surgery.

For mesothelioma patients who are good surgical candidates, chemotherapy may be used beforehand to shrink tumors or afterward to kill remaining cancer cells.

Some cancer centers also offer heated chemotherapy during surgical procedures. Known as heated intraoperative chemotherapy, this nonstandard treatment combines a macroscopic complete resection with heated chemotherapy drugs delivered directly into the area around the tumor.

Determining If You Are Eligible

The patient’s pleural mesothelioma stage and overall health will determine how and when chemotherapy is used.

Before beginning chemotherapy treatments, patients will go to a consultation visit with an oncologist. The doctor will discuss the patient’s medical history and results of a physical exam, cancer tests and scans.

A nurse also may provide extensive chemotherapy education at this time. Each patient will learn how the chemotherapy will be administered, expected side effects and information on how to best manage side effects.

Pleural Mesothelioma Information & Help

Free Treatment Guide

mesothelioma packet

Chemotherapy Drugs for Pleural Mesothelioma

Often, your doctor will prescribe two or more chemotherapies to be given together. This can provide the best cancer cell killing effect.

For pleural mesothelioma patients who are healthy enough to receive multiple chemotherapy drugs at once, the standard of care is Alimta (pemetrexed) plus cisplatin or carboplatin.

This combination of Alimta and a platinum drug is considered standard of care for pleural mesothelioma.

Although oncologists can offer other chemotherapy drugs if the standard of care is not an option, the combination of Alimta and a platinum drug is the only FDA-approved chemotherapy for the treatment of pleural mesothelioma.

If a person’s health or prior treatments prevent standard of care chemotherapy, other pleural mesothelioma treatments include:

Your doctor will determine which chemotherapy plan is best for you. If you do not tolerate a particular drug, they can switch you to a different medication.

A 2018 study published in OncoImmunology noted the addition of a cancer vaccine called TroVax led to a measurable immune response in the majority of recipients. The authors documented 70 percent of patients had stable disease during the short-term study.

Although this treatment is not yet available to all mesothelioma patients, the researchers recommended the chemotherapy plus cancer vaccine combination be moved to larger, phase III clinical trials.

How Is Chemotherapy Given to Each Patient?

Chemotherapy room
A typical chemotherapy infusion room.

The most common way to provide chemotherapy is through an IV. Pharmacists and nurses are involved in determining the appropriate chemotherapy dose for each patient and administering the drugs.

These procedures take place in a cancer center, chemotherapy infusion facility or in a hospital. Most chemotherapy is provided in an outpatient setting, though some patients may be admitted to the hospital for a few days if closer monitoring is part of the treatment plan.

Chemotherapy is typically given in cycles of once every few weeks followed by a break. Sessions may take minutes to several hours.

Once the chemotherapy is delivered, your nurse or doctor will check your vital signs again and discuss side-effect management. The exact treatment schedule and how long the drug is given during each session will vary for each patient, depending upon their health and optimal treatment plan.

Some patients may be eligible for oral chemotherapy, which is taken as a pill. Your oncologist will determine if it’s best for you to receive pleural mesothelioma treatments through an IV or with a pill.

Pleural Mesothelioma Chemotherapy Side Effects

The side effects of chemotherapy can be challenging, although newer pain and anti-nausea medications offer patients the ability to undergo treatment while maintaining good quality of life.

Even with excellent side-effect management, you may need to be monitored by your doctor in order to avoid any life-threatening consequences of chemotherapy.

Most side effects will decrease once therapy is complete, but others may take longer to resolve, and some may be permanent.

Ask your oncologist or nurse if you have questions about which side effects to expect, when you will experience them and how long they will last.

Being prepared and knowing what to expect will help you get the benefits of pleural mesothelioma chemotherapy while keeping side effects under control.

Common Chemotherapy Side Effects

If your doctor expects you to experience low white blood cell counts, they will give you special instructions for minimizing your risk of infection. This may include how to prepare foods, places to avoid and special hygiene precautions.

Are Chemotherapy Side Effects Manageable?

There are many ways to manage chemotherapy side effects.

Medications, dietary changes and supportive care all help patients gain the most benefit from pleural mesothelioma chemotherapy drugs while minimizing the downsides of these treatments.

When side effects are properly managed, chemotherapy — alone or in combination with surgery and radiation therapy — offers many patients good quality of life and longer survival.

If you experience any severe side effects, especially a fever, signs of infection, or the presence of blood in the urine, call your doctor or nurse right away.

Rare and Serious Chemotherapy Side Effects

Certain chemotherapy side effects are very serious. These symptoms should be reported to your cancer care team immediately. They can signal an infection or a severe medication reaction.

Call your oncology team immediately if you have:

Severe chemotherapy reactions should be reported to the U.S. Food and Drug Administration. This information helps doctors and researchers more effectively tailor future treatment for all patients receiving these same chemotherapy drugs.

How Will You Feel After Chemotherapy?

Some people feel fatigued immediately after chemotherapy and should plan on resting the rest of the day. Others feel fine on the day of treatment and only experience tiredness several days later. Ask your medical care team what to expect.

To minimize the risk of dehydration and constipation, drink plenty of fluids after each chemotherapy session. This will help your body process the drugs properly and support the health of your liver and kidneys during treatment.

You may need to avoid crowds and sick people because your immune system will be compromised for a time after each cycle of chemotherapy. If you develop any severe side effects, including a fever, vomiting, difficulty breathing or extreme fatigue, contact your oncologist immediately.

Even if you are taking medications to manage side effects, you may need adjustments to those drugs. Some people require different forms of toxicity management such as a patch to diminish nausea or lessen pain instead of a pill.

Even if you are not yet experiencing side effects, take your medications exactly as prescribed. For most people, it is far easier to prevent side effects than to try to relieve them once they start.


Snehal Smart, M.D.

Snehal Smart, M.D.

Snehal Smart is the Pleural Mesothelioma Center’s in-house medical doctor, serving as both an experienced Patient Advocate and an expert medical writer for the website. When she is not providing one-on-one assistance to patients, Dr. Snehal stays current on the latest medical research, reading peer-reviewed studies and interviewing oncologists to learn about advancements in diagnostic tools and cancer treatments.

Medically Reviewed By Dr. Joanne Getsy
Last Modified May 8, 2019

7 Cited Article Sources

  1. American Society of Clinical Oncology. (n.d.). What to expect when having chemotherapy. Retrieved from http://www.cancer.net/navigating-cancer-care/how-cancer-treated/chemotherapy/what-expect-when-having-chemotherapy
  2. Ceresoli, G. L., Zucali, P. A., Favaretto, A. G., Grossi, F., Bidoli, P., Conte, G. D., … & Santoro, A. (2006). Journal of Clinical Oncology, 24(9): 1443-1448. doi: 10.1200/JCO.2005.04.3190
  3. Gourdar, R. K. (2008). Review of pemetrexed in combination with cisplatin for the treatment of malignant pleural mesothelioma. Journal of Therapeutics and Clinical Risk Management, 4(1): 205-211.
  4. Nowak, A.K., Byrne, M.J., Williamson, R., Ryan, G., Segal, A., Fielding, D., … & Robinson, W.S. (2002). A multicenter phase II study of cisplatin and gemcitabine for malignant mesothelioma. British Journal of Cancer, 87(5): 491-496. doi: 10.1038/sj.bjc.6600505
  5. Pass, I., Vogelzang, N., Carbone, M. Malignant Mesothelioma: Advances in Pathogenesis, Diagnosis, and Transitional Therapies. Springer: New York. 2005.
  6. Scherpereel, A., Berghmans, T., Lafitte, J.J., Colinet, B., Richez, M., Bonduelle, Y., … & Sculier, J.P. (2011). Valproate-doxorubicin: Promising therapy for progressing mesothelioma. A phase II study. European Respiratory Journal, 37(1): 129-135. doi: 10.1183/09031936.00037310
  7. Stebbing, J., Powles, T., McPherson, K., Shamash, J., Wells, P., Sheaff, M.T., … & Stelle, J.P. (2009). The efficacy and safety of weekly vinorelbine in relapsed malignant pleural mesothelioma. Lung Cancer, 63(1): 94-97. doi: 10.1016/j.lungcan.2008.04.001

Free Mesothelioma Informational Packet

Get Yours Now

Get Help Finding a Doctor

Get Help Now

VA Claim Help For Veterans

Get Help Now

Our Certifications

McAfee SECURE sites help keep you safe from identity theft, credit card fraud, spyware, spam, viruses and online scams

Sponsored by The Peterson Firm, 1050 30th Street NW, Washington, DC 20007 © 2019 PleuralMesothelioma.com

View free resources for patients and families

Mesothelioma Information Packet

Get Yours Now
Packet
Chat live with a patient advocate now loading spinner