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Sarcomatoid Mesothelioma

Approximately 10 to 20 percent of pleural mesothelioma cases are the sarcomatoid cell type. This is the most aggressive form of the asbestos-related cancer. An accurate diagnosis is important for ensuring patients receive the best treatment.

Sarcomatoid cell pleural mesothelioma tends to be more aggressive and more resistant to cancer therapy compared with other mesothelioma cell types.

These tumors also are referred to as sarcomatous, spindled or diffuse malignant fibrous mesothelioma.

What Do Sarcomatoid Mesothelioma Cells and Tumors Look Like?

Sarcomatoid cells are one of three designations for pleural mesothelioma cells. They are spindle shaped and have an overlapping appearance within a tumor.

As they form tumors, sarcomatoid cells most often appear as small nodules or groupings scattered across the surface of the pleura — the thin membranes lining the chest cavity and surrounding the lungs.

The nodules can merge to form a sheet-like tumor on the lining around the lungs. Because the tumors tend to spread out over a larger area, they can be difficult to treat effectively.

In rare cases, a single sarcomatoid pleural mesothelioma tumor mass may form. This also can be challenging to treat. Sometimes the tumor has grown into the chest wall and it cannot be removed surgically.

Sarcomatoid Mesothelioma
Sarcomatoid mesothelioma cell.

What Are the Symptoms of Sarcomatoid Pleural Mesothelioma?

According to a 2019 Expert Review of Respiratory Medicine article, nonspecific symptoms of pleural mesothelioma can include cough, shortness of breath, chest wall pain, weight loss and fatigue.

Symptoms tend to be similar regardless of the mesothelioma cell type.

Many less serious diseases share these signs. This makes diagnosing pleural mesothelioma challenging, because the cancer is easily mistaken for asthma, bronchitis or pneumonia.

When a patient visits their doctor with complaints of shortness of breath or persistent cough, they may be treated with an inhaler or antibiotics first.

Mesothelioma is rare, and many primary care physicians will not consider it.

When things worsen or do not improve, the doctor may refer the patient to a pulmonologist for additional lung tests or physical exams.

Pleural effusion — the accumulation of fluids around the lungs — tends to be less common with sarcomatoid mesothelioma compared with other forms of the disease. If it does occur, it is typically accompanied by shortness of breath and chest pain.

Because sarcomatoid tumors can grow into the chest wall, some patients experience significant chest pain.

Other potential pleural mesothelioma symptoms include wheezing, fever or night sweats, muscle weakness, loss of appetite and trouble swallowing.

Why Is the Sarcomatoid Cell Type Difficult to Diagnose?

Because symptoms are nonspecific, diagnosing any type of pleural mesothelioma can be challenging.

Sarcomatoid mesothelioma presents additional difficulties, because the tumors can resemble benign (noncancerous) conditions or other types of cancer.

Under a microscope, sarcomatoid tissue samples can appear similar to sarcoma, fibrosarcoma, fibrous pleurisy, malignant fibrous histiocytoma, localized fibrous tumors, pleural liposarcoma or metastatic renal cell carcinoma.

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How Is Sarcomatoid Pleural Mesothelioma Diagnosed?

Diagnosis typically starts with imaging studies such as X-rays, a CT scan or an MRI. These tests cannot confirm mesothelioma but can reveal abnormalities in the lungs.

If cancer is suspected, a surgeon can review the imaging studies and make a plan to obtain a biopsy or multiple biopsies (tissue samples) of the tumor.

For patients with widespread pleural mesothelioma or multiple tumors, removing the entire tumor may not be an option. This makes the biopsy the most important diagnostic tool.

Surgeons often obtain biopsy samples using thoroscopy or video-assisted thoracic surgery procedures, which allows the surgeon to view the tumor during sampling. This increases the chances of an accurate sarcomatoid cell pleural mesothelioma diagnosis.

If you suspect you may have an asbestos-related disease, seek out a mesothelioma specialty cancer care team. This group is more likely to include a pathologist who is familiar with the disease and the American Society of Clinical Oncology 2018 pleural mesothelioma treatment guidelines.

This is important because the guidelines provide pathology testing recommendations.

Why Is Accurate Sarcomatoid Cell Type Diagnosis Important?

If you want to participate in a pleural mesothelioma clinical trial, your oncologist needs to know as much about your tumor as possible.

Your medical team can use these details to help you find a clinical trial to best match your needs and type of mesothelioma.

In a 2019 study published in Pathology International, researchers described an example of how this detailed cell information may help patients. The authors identified details about one patient’s epithelial mesothelioma tumor.

They found specific call markers indicating the cancer was susceptible to newer immunotherapy drugs. Without the detailed pathology report, oncologists wouldn’t know this is a possibility.

Sarcomatoid is the most aggressive cell type of mesothelioma. Access to newer, cutting-edge therapies can be an important part of improving length and quality of life.

How Does a Sarcomatoid Diagnosis Affect Treatment?

Most patients with pleural mesothelioma are treated based on the stage of cancer and tumor location, but sarcomatoid cancer can be more aggressive than other types.

Obtaining an accurate sarcomatoid diagnosis provides important information to your medical team for planning treatment.

While some pleural mesothelioma tumors can be removed with surgery, the structure and extent of sarcomatoid tumors sometimes makes surgery impossible.

However, this doesn’t mean you can’t get other life-extending treatments. A combination of chemotherapy and radiation therapy may be used in an approach called multimodal therapy.

Clinical trials for sarcomatoid pleural mesothelioma also are an option. Seeking care from a specialized mesothelioma program can improve treatment options and resources for patients as well.


Snehal Smart, M.D.

Snehal Smart, M.D.

Snehal Smart is the Pleural Mesothelioma Center’s in-house medical doctor, serving as both an experienced Patient Advocate and an expert medical writer for the website. When she is not providing one-on-one assistance to patients, Dr. Snehal stays current on the latest medical research, reading peer-reviewed studies and interviewing oncologists to learn about advancements in diagnostic tools and cancer treatments.

Medically Reviewed By Dr. Joanne Getsy
Last Modified February 27, 2019

8 Cited Article Sources

  1. Harris, E.J.A. et al. (2019, January 16). Diagnosis of asbestos-related lung diseases. Retrieved from https://www.tandfonline.com/doi/full/10.1080/17476348.2019.1568875
  2. Husain, A.N. et al. (2018, January). Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group. Retrieved from https://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2017-0124-RA
  3. Kindler, H. et al. (2018, May 1). Treatment of Malignant Pleural Mesothelioma: American Society of Clinical Oncology Clinical Practice Guideline. Retrieved from http://ascopubs.org/doi/pdf/10.1200/JCO.2017.76.6394
  4. Huaux, F. (2018, November 19). Emerging Role of Immunosuppression in Diseases Induced by Micro- and Nano-Particles: Time to Revisit the Exclusive Inflammatory Scenario. Retrieved from https://www.frontiersin.org/articles/10.3389/fimmu.2018.02364/full
  5. Rossini, M. et al. (2018, April 3). New Perspectives on Diagnosis and Therapy of Malignant Pleural Mesothelioma. Retrieved from https://www.frontiersin.org/articles/10.3389/fonc.2018.00091/full
  6. Berg, K.B. and Churg, A. (2017, September). GATA3 Immunohistochemistry for Distinguishing Sarcomatoid and Desmoplastic Mesothelioma From Sarcomatoid Carcinoma of the Lung. Retrieved from https://www.ingentaconnect.com/content/wk/ajsp/2017/00000041/00000009/art00008
  7. Marchevsky, A.M. et al. (2017, September). The differential diagnosis between pleural sarcomatoid mesothelioma and spindle cell/pleomorphic (sarcomatoid) carcinomas of the lung: evidence-based guidelines from the International Mesothelioma Panel and the MESOPATH National Reference Center. Retrieved from https://www.sciencedirect.com/science/article/pii/S0046817717302678
  8. Kinoshita, Y. et al. (2018, November). A combination of MTAP and BAP1 immunohistochemistry is effective for distinguishing sarcomatoid mesothelioma from fibrous pleuritis. Retrieved from https://www.lungcancerjournal.info/article/S0169-5002(18)30578-6/fulltext

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